Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs

Journal of Veterinary Internal Medicine

M.S. Kraus¹  K.M. Rassnick¹  J.J. Wakshlag¹  A.R.M. Gelzer¹  A.S. Waxman¹  A.M. Struble¹ 

[1] Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY

关键词: 25‐hydroxyvitamin D3;    Canine;    Cardiology;   

DOI  :  10.1111/jvim.12239

来源: Wiley

【 摘 要 】

Abstract

Background

Vitamin D plays a pivotal role in cardiac function, and there is increasing evidence that vitamin D deficiency is associated with the development of congestive heart failure (CHF) in people.

Hypothesis

Serum vitamin D concentration is lower in dogs with CHF compared with unaffected controls and serum vitamin D concentration is associated with clinical outcome in dogs with CHF.

Animals

Eighty-two client-owned dogs.

Methods

In this cross-sectional study, we examined the association between circulating 25-hydroxyvitamin D [25(OH)D], a measure of vitamin D status, and CHF in dogs. In the prospective cohort study, we examined whether 25(OH)D serum concentration was associated with clinical outcome in dogs with CHF.

Results

Mean 25(OH)D concentration (100 ± 44 nmol/L) in 31 dogs with CHF was significantly lower than that of 51 unaffected dogs (123 ± 42 nmol/L; P = .023). The mean calculated vitamin D intake per kg of metabolic body weight in dogs with CHF was no different from that of unaffected dogs (1.37 ± 0.90 μg/kg metabolic body weight versus 0.98 ± 0.59 μg/kg body weight, respectively, P = .097). There was a significant association of serum 25(OH)D concentration on time to clinical manifestation of CHF or sudden death (P = .02).

Conclusion and Clinical Relevance

These findings suggest that low concentrations of 25(OH)D may be a risk factor for CHF in dogs. Low serum 25(OH)D concentration was associated with poor outcome in dogs with CHF. Strategies to improve vitamin D status in some dogs with CHF may prove beneficial without causing toxicity.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine