Sensory Nerve Conduction and Somatosensory Evoked Potentials of the Trigeminal Nerve in Horses with Idiopathic Headshaking

Journal of Veterinary Internal Medicine

M. Aleman¹  D.C. Williams²  R.J. Brosnan³  J.E. Nieto³  K.J. Pickles¹  J. Berger²  R.A. LeCouteur³  T.A. Holliday³ 

[1] Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA;Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA;Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA

关键词: Electrophysiology;    Equine;    Neuralgia;    Pain;    Trigeminal;   

DOI  :  10.1111/jvim.12191

来源: Wiley

【 摘 要 】

Abstract

Background

Idiopathic headshaking (HSK) in horses is a distressing disorder in which the etiology and pathophysiology are unknown.

Hypothesis

Differences in sensory function of the trigeminal nerve exist between healthy and affected horses.

Animals

Six healthy mature geldings and 6 mature geldings with idiopathic HSK.

Methods

Prospective study. Sensory nerve action and somatosensory evoked potentials studies were performed. The stimulus site comprised the gingival mucosa dorsal to the maxillary canine. A pair of recording electrodes was placed along the sensory pathway of the trigeminal complex at the infraorbital nerve (R1), maxillary nerve (R2), spinal tract of trigeminal (R3), and somatosensory cortex (R4). Sensory nerve action potential latency (ms), amplitude (μV), duration (ms), area under the curve (μVms), and conduction velocity (m/s) were calculated.

Results

Threshold for activation of the infraorbital branch of the trigeminal nerve was significantly different between 5 affected (≤5 mA) and 6 control horses (≥10 mA). After initiation of an action potential, there were no differences in all parameters measured and no differences between left and right sides. A horse with seasonal HSK tested during a time of no clinical manifestations showed a threshold for activation similar to control horses.

Conclusions and Clinical Importance

This study confirms involvement of the trigeminal nerve hyperexcitability in the pathophysiology of disease. Further, results might support a functional rather than a structural alteration in the sensory pathway of the trigeminal complex that can be seasonal. The horse could serve as a natural animal model for humans with idiopathic trigeminal neuralgia.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine