Background
Pulmonary embolism (PE) is a complication of systemic disease in dogs. Antemortem diagnosis is challenging because of the lack of a confirmatory test.
Journal of Veterinary Internal Medicine | |
Diagnostic Utility of D‐Dimer Concentrations in Dogs with Pulmonary Embolism | |
S.E. Epstein1  K. Hopper1  M.S. Mellema1  | |
[1]Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA | |
关键词: Biomarker; Coagulation; Respiratory distress; Thromboembolism; | |
DOI : 10.1111/jvim.12177 | |
来源: Wiley | |
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Pulmonary embolism (PE) is a complication of systemic disease in dogs. Antemortem diagnosis is challenging because of the lack of a confirmatory test.
To retrospectively determine the diagnostic utility of D-dimer concentrations in dogs with necropsy-confirmed PE.
Ten dogs with PE confirmed at necropsy that had D-dimer concentrations measured and 10 control dogs with D-dimer concentrations available that lacked PE on necropsy.
The computerized medical record database was searched for dogs with necropsy-confirmed PE that had D-dimer concentrations measured at that visit. An age-, sex-, and breed-matched control group was identified. Signalment, location of PE, and coagulation profiles were collected. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated using a D-dimer concentration of 250 ng/mL.
Coagulation profiles were not different between dogs with and without PE. Using 250 ng/mL as a cut-off D-dimer concentration, the sensitivity and specificity were 80 and 30%, respectively, for the diagnosis of PE. The NPV and PPV were 60 and 53.0%, respectively. D-dimer concentration <103 ng/mL had 100% sensitivity for ruling out PE and no value was 100% specific.
D-dimer concentrations <250 ng/mL have a high sensitivity for the absence of PE, but PE still can occur in dogs with a normal D-dimer concentration. Increased D-dimer concentrations are not specific for PE.
Unknown
Copyright © 2013 by the American College of Veterinary Internal Medicine
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