Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

Journal of Veterinary Internal Medicine

K.M. Meurs⁶  J.A. Stern⁶  D.D. Sisson¹  M.D. Kittleson²  S.M. Cunningham⁴  M.K. Ames⁶  C.E. Atkins⁶  T. DeFrancesco⁶  T.E. Hodge⁶  B.W. Keene⁶  Y. Reina Doreste⁶  M. Leuthy³  A.A. Motsinger-Reif⁵ 

[1] Oregon State University College of Veterinary Medicine, Corvalis, OR;University of California-Davis School of Veterinary Medicine, Davis, CA;Chicago Veterinary and Emergency Center, Chicago, IL;Cummings School of Veterinary Medicine at Tufts, North Grafton, MA;North Carolina State University College of Agricultural and Life Sciences and College of Physical and Mathematical Sciences, Raleigh, NC;North Carolina State University College of Veterinary Medicine, Raleigh, NC

关键词: Boxer;    Dilated cardiomyopathy;    Mutation;    Striatin;   

DOI  :  10.1111/jvim.12163

来源: Wiley

【 摘 要 】

Abstract

Background

Myocardial disease in the Boxer dog is characterized by 1 of 2 clinical presentations, dilated cardiomyopathy (DCM) characterized by ventricular systolic dysfunction, dilatation and tachyarrhythmias, and arrhythmogenic right ventricular cardiomyopathy (ARVC) characterized by ventricular tachyarrhythmias, syncope, and sudden death. Boxer ARVC has been associated with a deletion in the striatin gene in some families.

Hypothesis/Objectives

We hypothesized that both presentations represent a single disease, and the development of DCM in the Boxer is associated with the striatin deletion.

Animals

Thirty-three adult Boxer dogs with DCM, 29 adult Boxer dogs with the striatin deletion and ARVC, and 16 Boxers without cardiac disease.

Methods

DNA samples were evaluated for the striatin deletion. Association of the deletion with the DCM phenotype was tested by a Fisher's exact test. T-tests were used to evaluate potential differences between the positive heterozygous and positive homozygous groups with DCM with regard to age, LVIDD, LVIDS, and FS%.

Results

Thirty of 33 dogs with DCM were positive for the striatin deletion. The striatin mutation and the homozygous genotype were strongly associated with the DCM phenotype (P < .001 and P = .005). There was no statistical difference between the heterozygous and homozygous groups with regard to age and echocardiographic measurements.

Conclusions and Clinical Importance

This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype. The observation that 3/33 dogs developed DCM and lacked the striatin mutation suggests that there is at least 1 other cause of DCM in the Boxer dog.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine