Hypovitaminosis D in Dogs with Spirocercosis

Journal of Veterinary Internal Medicine

C.T. Rosa¹  J.P. Schoeman¹  J.L. Berry²  R.J. Mellanby³ 

[1] Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa;Department of Medicine, Vitamin D Research Group, Manchester Royal Infirmary, Manchester, UK;Division of Veterinary Clinical Studies, The Royal (Dick) School of Veterinary Studies, Hospital for Small Animals, Easter Bush Veterinary Centre, The University of Edinburgh, Midlothian, UK

关键词: Calcidiol;    Dog;    Neoplasia;    Vitamin D;   

DOI  :  10.1111/jvim.12161

来源: Wiley

【 摘 要 】

Abstract

Background

Spirocercosis in dogs is characterized by esophageal nodules that can undergo neoplastic transformation. Hypovitaminosis D has been associated with neoplasia formation. We hypothesized hypovitaminosis D in neoplastic spirocercosis and that it could be a risk factor for neoplastic transformation.

Objective

To measure and compare vitamin D status, assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations in non-neoplastic (n = 25) and neoplastic (n = 26) spirocercosis client-owned dogs and healthy dogs (n = 24).

Animals

Twenty-five non-neoplastic dogs, 26 neoplastic dogs, and 24 healthy dogs.

Methods

Fifty-one dogs were randomly selected from 119 dogs diagnosed with spirocercosis presenting to our hospital, and further divided into non-neoplastic or neoplastic groups. Exclusion criteria included dogs less than 1 year old, with concurrent diseases, received corticosteroids, or treated prophylactically for spirocercosis. Serum 25(OH)D concentration was measured by high-performance liquid chromatography. Spirocercosis dogs' appetites were graded and compared.

Results

Serum 25(OH)D concentrations were significantly different among all groups (P < .001). 25-Hydroxyvitamin D concentrations were significantly lower in neoplastic group (median 30.7 nmol/L [range 14.7–62.2]) compared to non-neoplastic (median 52.7 nmol/L [range 19.1–129.7, P < .05]) and healthy groups (median 74.6 nmol/L [range 37.4–130.5, P < .005]). 25-hydroxyvitamin D concentrations were significantly lower in non-neoplastic spirocercosis dogs compared to healthy ones (P < .05). Neoplastic and non-neoplastic spirocercosis dogs had similar appetite scores (P = 1.0). 25-Hydroxyvitamin D concentrations were not significantly different between dogs with normal (P = .087) and abnormal (P = .125) appetites within neoplastic and non-neoplastic spirocercosis groups.

Conclusions and Clinical Importance

Further studies are warranted to determine potential use of vitamin D treatment in spirocercosis and explore role of hypovitaminosis D in pathogenesis of malignant transformation.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine