A Single Sample Method for Estimating Glomerular Filtration Rate in Cats

Journal of Veterinary Internal Medicine

N.C. Finch²  R. Heiene¹  J. Elliott²  H.M. Syme² 

[1] Norwegian School of Veterinary Science, Oslo, Norway;Royal Veterinary College, London, UK

关键词: Clearance;    Function;    Iohexol;    Renal;   

DOI  :  10.1111/jvim.12089

来源: Wiley

【 摘 要 】

Abstract

Background

Validated methods of estimating glomerular filtration rate (GFR) in cats requiring only a limited number of samples are desirable.

Hypothesis/Objectives

To test a single sample method of determining GFR in cats.

Animals

The validation population (group 1) consisted of 89 client-owned cats (73 nonazotemic and 16 azotemic). A separate population of 18 healthy nonazotemic cats (group 2) was used to test the methods.

Methods

Glomerular filtration rate was determined in group 1 using corrected slope-intercept iohexol clearance. Single sample clearance was determined using the Jacobsson and modified Jacobsson methods and validated against slope-intercept clearance. Extracellular fluid volume (ECFV) was determined from slope-intercept clearance with correction for the 1 compartment assumption and by deriving a prediction formula for ECFV (ECFV_Predicted) based on the body weight. The optimal single sample method was tested in group 2.

Results

A blood sample at 180 minutes and ECFV_Predicted were optimal for single sample clearance. Mean ± SD GFR in group 1 determined using the Jacobsson and modified Jacobsson formulae was 1.78 ± 0.70 and 1.65 ± 0.60 mL/min/kg, respectively. When tested in group 2, the Jacobsson method overestimated multisample clearance. The modified Jacobsson method (mean ± SD 2.22 ± 0.34 mL/min/kg) was in agreement with multisample clearance (mean ± SD 2.19 ± 0.34 mL/min/kg).

Conclusions and Clinical Importance

The modified Jacobsson method provides accurate estimation of iohexol clearance in cats, from a single sample collected at 180 minutes postinjection and using a formula based on the body weight to predict ECFV. Further validation of the formula in patients with very high or very low GFR is required.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine