Peri‐articular Histiocytic Sarcoma and Previous Joint Disease in Bernese Mountain Dogs

Journal of Veterinary Internal Medicine

L. van Kuijk¹  K. van Ginkel⁷  J.P. de Vos¹  M.J. Brearley²  J. Butinar⁶  I. Gielen³  E. van Garderen⁵  K. Chiers⁴ 

[1] De Ottenhorst, Veterinary Oncology Referral Centre, Terneuzen, The Netherlands;The Queen's Veterinary School Hospital, University of Cambridge, Cambridge, UK;Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;Laboratory for Pathology and Histology, Animal Health Service, Deventer, The Netherlands;Animal Hospital Postojna, Postojna, Slovenia;Roosevelt Academy, Middelburg, The Netherlands

关键词: Arthritis;    CD18;    Dendritic cells;    Pancytokeratin;    Synovium;   

DOI  :  10.1111/jvim.12059

来源: Wiley

【 摘 要 】

Abstract

Background

Peri-articular histiocytic sarcoma (PAHS) occurs in dogs, including Bernese Mountain Dogs (BMD). An etiologic relationship with previous joint disease has not been documented.

Hypothesis

Peri-articular histiocytic sarcoma in BMD will be more frequently encountered around previously diseased joints compared with normal joints.

Animals

920 European BMD.

Methods

A retrospective study, in which data were obtained through an Internet questionnaire and from 2 veterinary pathology laboratories. Archived samples of hematoxylin-eosin (H&E) staining diagnosed PAHS and synovial cell sarcoma (SCS) were immunolabeled with CD18 and pancytokeratin. Descriptive, comparative, and actuarial statistics comprise the data analysis.

Results

All primary synovial tumors were identified as PAHS based on their morphology, positive CD18, and negative pancytokeratin labeling. Joint disease was diagnosed in 226 BMD, of which 15 developed PAHS in a previously diseased joint and 3 in a nondiseased joint. Of the remaining 694 BMD without joint disease, 9 developed PAHS. The odds ratio for a dog with previous joint disease developing PAHS is calculated as 5.4 (95% CI: 2.3–12.5; P < .0001) compared with no previous joint problem. A significant association between previous joint disease and PAHS in the same joint was demonstrated for the left elbow (P = .016), right elbow (P = .006), right shoulder (P = .047), left and right stifle (P < .001), and left carpal joint (P = .010).

Conclusions and Clinical Importance

The results of this study suggest a relation between previous joint disease and the development of PAHS in the same joint of European BMD. Owners of BMD should monitor dogs for peri-articular swellings, particularly around previously diseased joints.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine