Alterations in Adipokines in Feline Hepatic Lipidosis

Journal of Veterinary Internal Medicine

M. Mazaki-Tovi³  S.K. Abood²  G. Segev¹ 

[1]Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel

[2]Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI

[3]Department of Pathobiology and Diagnostic Investigation, Diagnostic Center for Population and Animal Health, East Lansing, MI

关键词: Adiponectin;    Insulin;    Leptin;    Triglyceride;   

DOI  :  10.1111/jvim.12055

来源: Wiley

【 摘 要 】

Abstract

Background

Feline hepatic lipidosis (HL) is associated with alterations in lipid and carbohydrate metabolism. The adipokines, adiponectin, and leptin have lipid-lowering and insulin-sensitizing effects.

Hypothesis

Serum concentrations of adiponectin and leptin are altered in feline HL.

Animals

Client-owned cats: 55 healthy and 45 with liver disease.

Methods

Cats with liver disease were categorized as having HL (n = 20), HL and concurrent disease (n = 19), or other liver disease (n = 6), based on clinical signs, laboratory findings, abdominal ultrasound examination as well as liver cytopathology, histopathology, or both. Serum samples were collected and body condition score determined.

Results

Mean serum concentrations of adiponectin were higher in overweight cats with HL (4.5 μg/mL), HL and concurrent disease (4.4 μg/mL), or other liver disease (6.1 μg/mL), as compared with healthy cats (1.5 μg/mL; P < .001, P < .001, and P = .04, respectively). Mean serum concentration of leptin was higher in cats with HL (9.8 ng/mL) or HL and concurrent disease (10.7 ng/mL) than healthy cats (4.9 ng/mL, P < .001 and P < .001, respectively). Cats with other liver disease had leptin concentration (4.9 ng/mL) similar to healthy cats. Concentrations of adiponectin were correlated with alanine aminotransferase activity (r = 0.40, P = .0069), and concentrations of leptin were correlated with alkaline phosphatase activity (r = 0.42, P = .0051) in cats with liver disease.

Conclusions and Clinical Importance

Adipokine concentrations are altered in feline HL. Increased concentrations of adiponectin are related to liver disease, whereas increased concentrations of leptin are specifically related to HL.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine