Cardiac Changes in Horses with Atypical Myopathy

Journal of Veterinary Internal Medicine

T. Verheyen¹  A. Decloedt¹  D. De Clercq¹ 

[1] Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Belgium

关键词: Cardiac dysrhythmia;    Cardiac ultrasound;    QT interval;    Rhabdomyolysis;    Tissue Doppler imaging;   

DOI  :  10.1111/j.1939-1676.2012.00945.x

来源: Wiley

【 摘 要 】

Abstract

Background

Atypical myopathy (AM) is an acute, fatal rhabdomyolysis in grazing horses that mainly affects skeletal muscles. Postmortem examinations have shown that myocardial damage also occurs. Limited information is available on the effect of AM on cardiac function in affected and surviving horses.

Objectives

To describe electrocardiographic and echocardiographic changes associated with AM in the acute stage of the disease and after follow-up.

Animals

Horses (n = 12) diagnosed with AM in which cardiac ultrasound examination and ECG recording were available.

Methods

All horses underwent clinical examinations, serum biochemistry, electrocardiography, and echocardiography. Four surviving horses underwent the same examinations after 2–10 weeks.

Results

All but 1 horse had increased cardiac troponin I concentrations and 10 horses had ventricular premature depolarizations (VPDs). All horses had prolonged corrected QT (QT_cf) intervals on the day of admission and abnormal myocardial wall motion on echocardiography. One of the surviving horses still had VPDs and prolonged QT_cf at follow-up after 10 weeks.

Conclusions and Clinical Importance

The AM results in characteristic electrocardiographic and echocardiographic changes and may be associated with increased cardiac troponin I concentrations and VPDs. In survivors, abnormal cardiac function still may be found at follow-up after 10 weeks. Additional research in a larger group of horses is necessary to identify the long-term effects of AM on cardiac function.

【 授权许可】

Unknown   
Copyright © 2012 by the American College of Veterinary Internal Medicine