Disease Progression and Treatment Response of Idiopathic Epilepsy in Australian Shepherd Dogs

Journal of Veterinary Internal Medicine

J. Weissl¹  V. Hülsmeyer¹  C. Brauer³  A. Tipold³  L.L. Koskinen²  K. Kyöstilä²  H. Lohi²  C. Sauter-Louis⁴  M. Wolf¹ 

[1] Section of Neurology, Clinic of Small Animal Medicine, Ludwig-Maximilians-University, Munich, Germany;Department of Veterinary Biosciences and Research Programs Unit, Molecular Medicine, University of Helsinki and Folhälsan Research Center, Helsinki, Finland;Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany;Clinic for Ruminants, Ludwig-Maximilians-University, Munich, Germany

关键词: ABCB1(MDR1);    Canine;    Pharmacoresistance;    Seizure;   

DOI  :  10.1111/j.1939-1676.2011.00853.x

来源: Wiley

【 摘 要 】

Abstract

Background

Idiopathic epilepsy (IE) in Australian Shepherds (ASs) occurs worldwide but there is a lack of description of the epilepsy syndrome in this breed. The ABCB1-1Δ mutation is more prevalent in ASs than in many other dog breeds.

Hypothesis

Australian Shepherds suffer from a poorly controlled IE syndrome with prevailing severe courses. Seizure control and ABCB1-1Δ mutation might be related in this breed.

Animals

Fifty ASs diagnosed with IE and 50 unaffected ASs.

Methods

Predominant study design is a longitudinal cohort study. Pedigrees, medical records, seizure, and treatment data of ASs with IE were analyzed descriptively. Sex, color, and the ABCB1-1Δ genotype were compared between case and control groups and ASs with poorly or well-controlled seizures. Differences in survival times were assessed by logrank tests and Cox regression analysis.

Results

Idiopathic epilepsy in ASs is dominated by moderate and severe clinical courses with the occurrence of cluster seizures and status epilepticus and a high seizure frequency. Poor seizure control and a high initial seizure frequency (≥10 seizure days/first 6 months) are associated with shorter survival times (P < .05). Poor seizure control, unrelated to the ABCB1(MDR1) genotype, is evident in 56% of epileptic ASs. Pedigree analysis suggests a genetic basis.

Conclusion and Clinical Importance

Frequent severe clinical courses, poor seizure control unrelated to the ABCB1(MDR1) genotype, and a young age at death compromise animal welfare and warrant further genetic studies to unravel the underlaying molecular mechanisms of IE and seizure control in the breed.

【 授权许可】

Unknown   
Copyright © 2011 by the American College of Veterinary Internal Medicine