Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients

Thoracic Cancer

Omer Ayten¹  Dilaver Tas¹  Ersin Demirer¹  Oguzhan Okutan¹  Faruk Ciftci¹  Metin Aytekin²  Atilla Uysal³ 

[1] Department of Chest Diseases, GATA Haydarpasa Training Hospital, Istanbul, Turkey;Department of Pathobiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA;Department of Chest Diseases, Okmeydani Training Hospital, Istanbul, Turkey

关键词: angiopoietin 2;    bronchial lavage fluid;    lung cancer;    metastasis;    tumor stage;   

DOI  :  10.1111/j.1759-7714.2012.00128.x

来源: Wiley

【 摘 要 】

Abstract

Background:  Angiopoietin 2 (Ang-2) has an important role in tumor angiogenesis. In this study, Ang-2 levels of serum and bronchioloalveolar lavage fluids (BALF) in patients with lung cancer were measured and correlated with clinical and biochemical parameters.

Methods:  Thirty-five cases newly diagnosed with lung cancer and 18 controls with non-cancerous lung diseases were included in the study. Tumor histology, staging, metastasis, tumor markers, biochemical and clinical parameters were all recorded.

Results:  Serum Ang-2 levels were significantly higher in the lung cancer group compared to the control (lung cancer median: 2.42 ng/mL [2.19–2.98], control 0.67 [0.31–1.10]; P < 0.001), whereas Ang-2 levels in BALF were lower in the lung cancer group compared to the control (lung cancer median 0.41 ng/mL [0.22–0.79], control 0.67 [0.46–1.03]; P = 0.02). In the cancer group, higher serum Ang-2 levels (r = 0.52, P < 0.001) were associated with the stage of cancer. No significant correlation was observed between BALF Ang-2 levels and non-small cell lung cancer stages and small-cell lung cancer advanced stage (P = 0.793, r = 0.07). Serum Ang-2 levels were significantly higher in distant metastasis (M1) versus no distant metastasis (M0) (M1: 2.57 ng/mL [2.38–2.87], M0: 2.22 [1.49–2.40], P = 0.01). No significant correlation was observed between BALF Ang-2 levels and M1 (r = 0.11, P = 0.53).

Conclusions:  Serum Ang-2 levels were significantly higher in lung cancer patients and positive correlations were observed between serum Ang-2, tumor stage, and metastasis.

【 授权许可】

Unknown   
© 2012 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd