Prevalence, risk factors and survival of lung cancer in the idiopathic pulmonary fibrosis

Thoracic Cancer

Kyung Jong Lee⁴  Man Pyo Chung⁴  Young Whan Kim⁷  Jae Ho Lee⁷  Kyu-Sik Kim⁵  Jeong Seon Ryu⁸  Hong Lyeol Lee⁸  Sung Woo Park¹  Choon Sik Park¹  Soo-Tak Uh¹  Yong Chul Lee²  Seoung Ju Park²  Kwan Hyoung Kim⁶  Young June Jeon³  Won Il Choi³  Yong Bum Park¹¹  Dong Soon Kim^4,12  Sung Hwan Jeong^4,9  Jin Hwa Lee^4,10 

[1] Department of Internal Medicine, Soon Chun Hyang University College of Medicine, South Korea;Department of Internal Medicine, Chonbuk National University College of Medicine, South Korea;Department of Internal Medicine, Keimyung University School of Medicine, South Korea;Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;Department of Internal Medicine, Chonnam National University College of Medicine, South Korea;Department of Internal Medicine, Catholic University College of Medicine, South Korea;Department of Internal Medicine, Seoul National University College of Medicine, South Korea;Department of Internal Medicine, Inha University College of Medicine, South Korea;Department of Internal Medicine, Gachon University College of Medicine, South Korea;Department of Internal Medicine, Ewha Womans University College of Medicine, South Korea;Department of Internal Medicine, Hallym University College of Medicine, South Korea;Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, South Korea

关键词: idiopathic pulmonary fibrosis;    lung cancer;    prevalence;   

DOI  :  10.1111/j.1759-7714.2011.00107.x

来源: Wiley

【 摘 要 】

Abstract

Background:  The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF).

Methods:  IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical records retrospectively to evaluate the prevalence, risk factors and prognosis of lung cancer in IPF patients.

Results:  Among all patients with IPF, 114 cases (6.8%) had lung cancer with IPF. The incidence of lung cancer in patients with IPF was 1.03 persons per 100 person-year (25 patients/2408 years). Most cases of lung cancer (73/114, 68.9%) were located in IPF-associated areas; the lung cancer typically developed in peripheral and lower lobe areas. The study revealed that forced vital capacity (% predicted) at the initial diagnosis and development of lung cancer were independent prognostic factors in patients with IPF.

Conclusions:  Lung cancer in patients with IPF was significantly related with the IPF prognosis. An active evaluation should be performed in patients with IPF to detect lung cancer early.

【 授权许可】

Unknown   
© 2011 Tianjin Lung Cancer Institute and Blackwell Publishing Asia Pty. Ltd