Expression of nectin 3: Novel prognostic marker of lung adenocarcinoma

Thoracic Cancer

Yoshimasa Maniwa¹  Wataru Nishio¹  Yutaka Okita² 

[1] Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;Division of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

关键词: E‐cadherin;    lung cancer;    lung adenocarcinoma;    nectin‐3;    prognostic factor;   

DOI  :  10.1111/j.1759-7714.2011.00104.x

来源: Wiley

【 摘 要 】

Abstract

Background:  We investigated the prognostic significance of the immunoglobulin-like cell adhesion molecule nectin-3, a regulator of the formation of adherens junctions, in human lung adenocarcinoma.

Methods:  Tumor-tissue samples of 127 patients with surgically resected lung adenocarcinoma were used for analysis of the proteins expression by immunohistochemistry.

Results:  Of the 127 patients, 25% showed membranous expression of nectin-3, and others showed negative or cytoplasmic expression. Membranous expression of nectin-3 was found to be a prognostic factor for decreased overall survival on univariate analysis (P = 0.001). Multivariate Cox proportional hazards model analyses also revealed that membranous expression of nectin-3 turned out to be an independent prognostic factor (P = 0.048). Moreover, in tumors expressing membranous nectin-3, some tumors did not co-localize with E-cadherin, and the patients of such tumors showed poorer prognosis than other patients for overall survival on univariate analysis (P < 0.03). Conversely, membranous expression of nectin-3 with E-cadherin co-localization was found to associate with good prognosis of patients.

Conclusion:  Membranous expression of nectin-3 was an independent prognostic factor of lung adenocarcinoma, and it might play an important role in progression of the tumor.

【 授权许可】

Unknown   
© 2011 Tianjin Lung Cancer Institute and Blackwell Publishing Asia Pty. Ltd