Thoracic Cancer | |
Expression of nectin 3: Novel prognostic marker of lung adenocarcinoma | |
Yoshimasa Maniwa1  Wataru Nishio1  Yutaka Okita2  | |
[1] Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;Division of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan | |
关键词: E‐cadherin; lung cancer; lung adenocarcinoma; nectin‐3; prognostic factor; | |
DOI : 10.1111/j.1759-7714.2011.00104.x | |
来源: Wiley | |
【 摘 要 】
Background: We investigated the prognostic significance of the immunoglobulin-like cell adhesion molecule nectin-3, a regulator of the formation of adherens junctions, in human lung adenocarcinoma. Methods: Tumor-tissue samples of 127 patients with surgically resected lung adenocarcinoma were used for analysis of the proteins expression by immunohistochemistry. Results: Of the 127 patients, 25% showed membranous expression of nectin-3, and others showed negative or cytoplasmic expression. Membranous expression of nectin-3 was found to be a prognostic factor for decreased overall survival on univariate analysis (P = 0.001). Multivariate Cox proportional hazards model analyses also revealed that membranous expression of nectin-3 turned out to be an independent prognostic factor (P = 0.048). Moreover, in tumors expressing membranous nectin-3, some tumors did not co-localize with E-cadherin, and the patients of such tumors showed poorer prognosis than other patients for overall survival on univariate analysis (P < 0.03). Conversely, membranous expression of nectin-3 with E-cadherin co-localization was found to associate with good prognosis of patients. Conclusion: Membranous expression of nectin-3 was an independent prognostic factor of lung adenocarcinoma, and it might play an important role in progression of the tumor.Abstract
【 授权许可】
Unknown
© 2011 Tianjin Lung Cancer Institute and Blackwell Publishing Asia Pty. Ltd
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202107150006500ZK.pdf | 1449KB | download |