Time‐ and dose‐dependent effects of total‐body ionizing radiation on muscle stem cells

Physiological Reports

Shinya Masuda¹  Tsubasa Hisamatsu¹  Daiki Seko¹  Yoshishige Urata¹  Shinji Goto¹  Tao-Sheng Li¹ 

[1] Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

关键词: Hormesis;    low‐dose irradiation;    muscle stem cells;    satellite cells;    skeletal muscle;    tissue stem cells;   

DOI  :  10.14814/phy2.12377

来源: Wiley

【 摘 要 】

Abstract

Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of total-body γ-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to γ-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice.

【 授权许可】

CC BY   
© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

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