Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols

Physiological Reports

Xavier Holy¹  Laurent Bégot¹  Sylvie Renault³  Xavier Butigieg¹  Catherine André¹  Dominique Bonneau¹  Gustave Savourey² 

[1] Département des Services, IRBA, Brétigny-sur-Orge Cedex, France;Département des Facteurs Humains, IRBA Antenne La Tronche, La Tronche Cedex, France;Département Soutien Médico-Chirurgical des Forces, IRBA, Brétigny-sur-Orge Cedex, France

关键词: Hypercapnia;    hypovitaminosis D;    metabolic markers;    submariners;   

DOI  :  10.14814/phy2.12494

来源: Wiley

【 摘 要 】

Abstract

Within the framework of earlier publications, we have consistently dedicated our investigations to eliciting the effects of both seasonal vitamin D deficiency and submarine-induced hypercapnia on serum parameters for acid–base balance and bone metabolism in submariners over a 2-month winter (WP) or summer (SP) patrols. The latest findings reported herein, contribute further evidence with regard to overall physiological regulations in the same submariner populations that underwent past scrutiny. Hence, urine and blood samples were collected in WP and SP submariners at control prepatrol time as well as on submarine patrol days 20, 41, and 58. Several urine and serum metabolic markers were quantified, namely, deoxypyridinoline (DPD), lactate, albumin, creatinine, nonesterified fatty acids (NEFA), and ionized sodium (Na⁺) or potassium (K⁺), with a view to assessing bone, muscle, liver, or kidney metabolisms. We evidenced bone metabolism alteration (urine DPD, calcium, and phosphorus) previously recorded in submarine crewmembers under prolonged patrols. We also highlighted transitory modifications in liver metabolism (serum albumin) occurring within the first 20 days of submersion. We further evidenced changes in submariners’ renal physiology (serum creatinine) throughout the entire patrol time span. Measurements of ionic homeostasis (serum Na⁺ and K⁺) displayed potential seasonal impact over active ionic pumps in submariners. Finally, there is some evidence that submersion provides beneficial conditions prone to fend off seasonal lactic acidosis (serum lactate) detected in WP submariners.

【 授权许可】

CC BY   
© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

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