The obesity‐associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas

Physiological Reports

Arjen J. Boender¹  Margriet A. van Gestel¹  Keith M. Garner¹  Mieneke C. M. Luijendijk¹ 

[1] Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

关键词: AAV technology;    arcuate nucleus;    GWAS;    Negr1;    ventromedial hypothalamus;   

DOI  :  10.14814/phy2.12083

来源: Wiley

【 摘 要 】

Abstract

Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our results provide further support for a role of hypothalamic expressed Negr1 in the regulation of energy balance.

【 授权许可】

CC BY   
© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

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