Targeting the Notch signaling pathway in cancer therapeutics

Thoracic Cancer

Huajiao Guo³  Yi Lu³  Jianhua Wang¹  Xia Liu³  Evan T. Keller⁴  Qian Liu²  Qinghua Zhou² 

[1] Department of Biochemistry and Molecular & Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Shanghai, China;Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China;Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education, Nanning, China;Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA

关键词: Cancer;    Notch signaling pathway;    oncogene;    targeted therapeutics;    tumor suppressor gene;   

DOI  :  10.1111/1759-7714.12143

来源: Wiley

【 摘 要 】

Abstract

Despite advances in surgery, imaging, chemotherapy, and radiotherapy, the poor overall cancer-related death rate remains unacceptable. Novel therapeutic strategies are desperately needed. Nowadays, targeted therapy has become the most promising therapy and a welcome asset to the cancer therapeutic arena. There is a large body of evidence demonstrating that the Notch signaling pathway is critically involved in the pathobiology of a variety of malignancies. In this review, we provide an overview of emerging data, highlight the mechanism of the Notch signaling pathway in the development of a wide range of cancers, and summarize recent progress in therapeutic targeting of the Notch signaling pathway.

【 授权许可】

Unknown   
© 2014 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd