Histological subtypes of lung cancer in Chinese women from 2000 to 2012

Thoracic Cancer

Xiao Nong Zou²  Dongmei Lin⁶  Ann Chao⁵  Xia Wan⁷  Qinfu Feng⁴  Junling Li¹  Jie Yang³  Gong Huan Yang⁷ 

[1] Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China;National Office of Cancer Prevention and Control, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China;Office of Tobacco Control, Chinese Center for Disease Control and Prevention, Beijing, China;Department of Radiation Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China;Center for Global Health, National Cancer Institute, Bethesda, Maryland, USA;Department of Pathology, National Cancer Center, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China;Institute of Basic Medicine, Chinese Academy of Medical Sciences, Beijing, China

关键词: Chinese;    epidemiology;    female;    histology;    lung cancer;   

DOI  :  10.1111/1759-7714.12121

来源: Wiley

【 摘 要 】

Abstract

Background

The aim of the study was to characterize the histological and epidemiological features of lung cancer in Chinese women.

Methods

Demographic and histological information on female lung cancer cases identified during 1 January 2000 through 31 December 2012 from the Cancer Hospital of the Chinese Academy of Medical Sciences were collected. The International Classification of Diseases for Oncology system was used to classify the histological subtypes. Relative frequencies (RF) were estimated for major histological subtypes and compared by the years of diagnosis and birth, and among residential areas. Statistical differences were tested for RFs in the time periods with a trend test and with Pearson Chi square tests for distribution.

Results

Of 7070 female Chinese lung cancer cases, the major histological subtypes were adenocarcinoma (ADC) 65.79%; squamous cell carcinoma (SCC) 10.21%; small cell cancer 8.12%; large cell carcinoma, 2.79%; and adeno-squamous carcinoma (ASC), 2.19%. ADC increased, with RFs from 46.72% in the cases identified in 2000–2002 to 76.49% in 2011–2012 (Z = 16.998, P < 0.0001); SCC decreased from 15.69% to 5.97% (Z = −8.750, P < 0.0001). Compared to the cases identified in 2000–2006, the age-adjusted RFs of ADC in 2007–2012 consistently increased in all study areas.

Conclusion

The significant increase of ADC of the lung in Chinese women suggests that a persistently strong exposure to potential carcinogens in the Chinese population should be further and fully investigated.

【 授权许可】

Unknown   
© 2014 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd