Prognostic factors for patients with advanced non‐small cell lung cancer treated with gemcitabine‐platinum as first‐line therapy in an observational setting in China

Thoracic Cancer

Wenyu Ye³  Yicheng Yang²  Jin Wang³  Zbigniew Kadziola¹  Narayan Rajan⁴ 

[1] Real World Analytics, Eli Lilly GmbH, Vienna, Austria;ORCID:orcid.org/0000-0003-4267-3783;Lilly Suzhou Pharmaceutical Co. Ltd, Shanghai, China;Eli Lilly Australia Pty Ltd, Sydney, Australia

关键词: Advanced;    gemcitabine;    non‐small cell lung cancer;    platinum;    prognostic;   

DOI  :  10.1111/1759-7714.12095

来源: Wiley

【 摘 要 】

Abstract

Background

This study examined the prognostic factors associated with survival in advanced non-small cell lung cancer (NSCLC) patients receiving gemcitabine-platinum regimens as first-line therapy in real-world clinical settings in China.

Methods

Data was analyzed from a multinational, prospective, non-interventional, observational study of individuals receiving gemcitabine-platinum regimens as first-line therapy for NSCLC, focusing on 300 patients from mainland China. A Cox regression model was used to determine the association of 38 prognostic factors, including patient smoking characteristics, with overall survival.

Results

In these 300 patients, the mean age was 58.9 (±10.8) years, with males comprising 71% of the population. Thirty percent of patients had an Eastern Cooperative Oncology Group performance status (PS) of 0 and 70% had a PS of 1. The majority of patients had NSCLC of adenocarcinoma origin (57%). Multivariate Cox regression analyses adjusted for baseline factors revealed that gender, tumor (T) staging, metastasis (M) staging, liver metastases, serum albumin, and superior vena cava obstruction were significant prognostic factors. Smoking during therapy was not significantly associated with survival, although numbers were small for this variable (n = 16). Weight loss of >10% was a significant prognostic factor for adverse events.

Conclusions

Gender, T staging, M staging, liver metastases, superior vena cava obstruction, and serum albumin are prognostic factors affecting overall survival in mainland Chinese patients receiving first-line gemcitabine-platinum regimens for advanced NSCLC. These negative prognostic factors may warrant further investigation in clinical trials.

【 授权许可】

Unknown   
© 2014 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd