Human papillomavirus and non‐small cell lung cancer

Thoracic Cancer

Nan-Yung Hsu²  Hue Lee¹  Yun Yen³ 

[1]College of Medical Science and Technology, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan

[2]Division of Thoracic Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan

[3]International Cancer Institute, Taipei Medical University Hospital, Taipei, Taiwan

关键词: Carcinogenesis;    human papillomavirus;    lung cancer;   

DOI  :  10.1111/1759-7714.12030

来源: Wiley

【 摘 要 】

Abstract

Lung cancer is the most common cause of cancer-related deaths in the world, causing more than one million deaths worldwide each year. Human papillomavirus (HPV) are small non-enveloped DNA viruses that infect squamous epithelial cells. Relevant studies have reported lung cancer-related HPV infection rates that fluctuate between 10% and 80%, depending on the various research methods and geographical factors. Various scholars gathered statistics from global research reports and found that 22.4% of the patients with lung cancer presented with an HPV infection, which suggested that HPV infection may relate to the tumorigenesis of non-small cell lung cancer. This article will review the history and discovery of HPV, the correlation between HPV and lung cancer development, and carcinogenesis caused by HPV regulatory genes, such as p53, p21, p16INK4a, and genes related to hypermethylation and genome instability in lung cancer patients with HPV infection. In addition, because studies have highlighted the difference in clinical prognosis for HPV-positive and HPV-negative patients, articles demonstrating the correlation between HPV infection and prognosis for lung cancer patients will be reviewed.

【 授权许可】

Unknown   
© 2012 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd