Strategic Application of Residence‐Time Control in Continuous‐Flow Reactors

ChemistryOpen

Dr. István M. Mándity¹  Dr. Sándor B. Ötvös¹ 

[1]Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary

关键词: chemoselectivity;    continuous flow;    diastereoselectivity;    reactors;    residence time;   

DOI  :  10.1002/open.201500018

来源: Wiley

【 摘 要 】

Abstract

As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.