Cover Picture: Sterically Demanding Unsymmetrical Diaryl‐λ3‐iodanes for Electrophilic Pentafluorophenylation and an Approach to α‐Pentafluorophenyl Carbonyl Compounds with an All‐Carbon Stereocenter (ChemistryOpen 6/2014)

ChemistryOpen

Kohei Matsuzaki¹  Kenta Okuyama¹  Etsuko Tokunaga¹  Dr. Motoo Shiro² 

[1] Department of Nanopharmaceutical Science & Department of Frontier Materials, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan), Fax: [phone];Rigaku Corporation, 3-9-12 Mastubara-cho, Akishima, Tokyo 196-8666 (Japan)

关键词: asymmetric organocatalysis;    diaryl-λ3-iodanes;    electrophilic pentafluorophenylation;    palladium;   

DOI  :  10.1002/open.201480601

来源: Wiley

【 摘 要 】

Abstract

The cover picture shows the Japanese painting “Genshi-Chi” (“Primitive Land”) by Mami Shibata: our state-of-the-art reagent for pentafluorophenylation is realized by the cooperation of the halogens fluorine and iodine—elements from the primitive Earth. In the study, sterically demanding unsymmetrical pentafluorophenyl-triisopropylphenyl-λ³-iodane was developed as an effective reagent for the electrophilic pentafluorophenylation of various β-keto esters and a β-keto amide. 17 examples of α-pentafluorophenylated 1,3-dicarbonyl compounds with quaternary carbon centers are provided. For more details, see the Communication by Norio Shibata on 10.1002/open.201402045 ((p. 233 ff.))

【 授权许可】

Unknown   
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