Room Temperature, Metal‐Free Arylation of Aliphatic Alcohols

ChemistryOpen

Dr. Raju Ghosh¹  Erik Lindstedt¹  Dr. Nazli Jalalian¹ 

[1] Department of Organic Chemistry, Stockholm University, 10691 Stockholm (Sweden)

关键词: aliphatic alcohols;    alkyl aryl ethers;    arylation;    diaryliodonium salts;    hypervalent iodine;   

DOI  :  10.1002/open.201402006

来源: Wiley

【 摘 要 】

Abstract

Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under metal-free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields. Aryl groups with electron-withdrawing substituents are transferred most efficiently, and unsymmetric iodonium salts give chemoselective arylations. The methodology has been applied to the formal synthesis of butoxycaine.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

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