Difluoro‐ and Trifluoromethylation of Electron‐Deficient Alkenes in an Electrochemical Microreactor

ChemistryOpen

Dr. Kenta Arai¹  Kevin Watts¹ 

[1] School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (United Kingdom) http://www.cf.ac.uk/chemy/wirth

关键词: difluoroacetic acid;    electrochemistry;    flow chemistry;    microreactor;    radicals;    trifluoroacetic acid;   

DOI  :  10.1002/open.201300039

来源: Wiley

【 摘 要 】

Abstract

Electrochemical microreactors, which have electrodes integrated into the flow path, can afford rapid and efficient electrochemical reactions without redox reagents due to the intrinsic properties of short diffusion distances. Taking advantage of electrochemical microreactors, Kolbe electrolysis of di- and trifluoroacetic acid in the presence of various electron-deficient alkenes was performed under constant current at continuous flow at room temperature. As a result, di- and trifluoromethylated compounds were effectively produced in either equal or higher yields than identical reactions under batch conditions previously reported by Uneyamas group. The strategy of using electrochemical microreactor technology is useful for an effective fluoromethylation of alkenes based on Kolbe electrolysis in significantly shortened reaction times.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.