Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet‐Printed Gold Nanoparticle Arrays

ChemistryOpen

Colleen E. Krause¹  Brunah A. Otieno¹  Dr. Alina Latus¹  Dr. Ronaldo C. Faria²  Dr. Vyomesh Patel³  Dr. J. Silvio Gutkind³ 

[1] Department of Chemistry, University of Connecticut, Storrs, CT 0626 (USA);Departamento de Quimic, Universidade Federal de Sao Carlos, Sao Paulo (Brazil);Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD (USA)

关键词: cancer biomarkers;    electrochemistry;    inkjet‐printed arrays;    microfluidics;    sensors;   

DOI  :  10.1002/open.201300018

来源: Wiley

【 摘 要 】

Abstract

Off-line amplification: A low-cost inkjet-printed gold nanoparticle immunoarray was integrated into a microfluidic device for multiple protein determinations. The use of heavily labeled magnetic beads allows optimization either for ultrasensitive detection of biomarker proteins (low fg mL⁻¹ levels) or for rapid 8 min assays within clinically relevant detection ranges.

【 授权许可】

Unknown   
© 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.