The number of p16INK4a positive cells in human skin reflects biological age

Aging Cell

Mariëtte E.C. Waaijer³  William E. Parish¹  Barbara H. Strongitharm¹  Diana van Heemst³  Pieternella E. Slagboom⁴  Anton J.M. de Craen³  John M. Sedivy²  Rudi G.J. Westendorp³  David A. Gunn¹ 

[1] Unilever Discover, Colworth Science Park, Sharnbrook, Bedfordshire, UK;Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA;Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands;Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

关键词: p16INK4a;    biological age;    familial longevity;    cellular senescence;   

DOI  :  10.1111/j.1474-9726.2012.00837.x

来源: Wiley

【 摘 要 】

Summary

Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin.

【 授权许可】

Unknown   
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland