Aging Cell | |
Host cell factor 1 inhibits SKN‐1 to modulate oxidative stress responses in Caenorhabditis elegans | |
Gizem Rizki1  Colette Lafontaine Picard1  Charles Pereyra1  | |
[1] Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA | |
关键词: aging; DAF‐16; HCF‐1; oxidative stress; SKN‐1; transcription; | |
DOI : 10.1111/j.1474-9726.2012.00831.x | |
来源: Wiley | |
【 摘 要 】
Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.Summary
【 授权许可】
Unknown
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
【 预 览 】
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RO202107150004218ZK.pdf | 323KB | download |