Host cell factor 1 inhibits SKN‐1 to modulate oxidative stress responses in Caenorhabditis elegans

Aging Cell

Gizem Rizki¹  Colette Lafontaine Picard¹  Charles Pereyra¹ 

[1] Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA

关键词: aging;    DAF‐16;    HCF‐1;    oxidative stress;    SKN‐1;    transcription;   

DOI  :  10.1111/j.1474-9726.2012.00831.x

来源: Wiley

【 摘 要 】

Summary

Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.

【 授权许可】

Unknown   
© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland