Cellular organization of adult neurogenesis in the Common Marmoset

Aging Cell

Eva C. Bunk²  Sandra Stelzer²  Sven Hermann¹  Michael Schäfers¹  Stefan Schlatt³ 

[1] EIMI, European Institute for Molecular Imaging;ZMBE, Cell Biology, Stem Cell Biology and Regeneration Group;CeRa, Institute of Reproductive and Regenerative Biology, University of Münster, Münster, Germany

关键词: adult neurogenesis;    aging;    common marmoset;    neural stem cells;   

DOI  :  10.1111/j.1474-9726.2010.00639.x

来源: Wiley

【 摘 要 】

Summary

Adult neurogenesis within the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricle (LV) has been most intensely studied within the brains of rodents such as mice and rats. However, little is known about the cell types and processes involved in adult neurogenesis within primates such as the common marmoset (Callithrix jacchus). Moreover, substantial differences seem to exist between the neurogenic niche of the LV between rodents and humans. Here, we set out to use immunohistochemical and autogradiographic analysis to characterize the anatomy of the neurogenic niches and the expression of cell type–specific markers in those niches in the adult common marmoset brain. Moreover, we demonstrate significant differences in the activity of neurogenesis in the adult marmoset brain compared to the adult mouse brain. Finally, we provide evidence for ongoing proliferation of neuroblasts within both the SGZ and SVZ of the adult brain and further show that the age-dependent decline of neurogenesis in the hippocampus is associated with a decrease in neuroblast cells.

【 授权许可】

Unknown   
© 2010 The Authors. Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland