Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy

Clinical Case Reports

Nicole M. Maxwell⁴  Remington L. Nevin¹  Stephen Stahl⁷  Jerald Block⁸  Sarah Shugarts²  Alan H. B. Wu⁵  Stephen Dominy⁵  Miguel Alonso Solano-Blanco⁶  Sharon Kappelman-Culver³  Christopher Lee-Messer⁹  Jose Maldonado⁹ 

[1] Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;Kaiser Permanente, Berkeley, California;In Private Practice, Lafayette, California;University of San Francisco, San Francisco, California;University of California, San Francisco, San Francisco, California;Centro de Especialidades Medicas de Siguatepeque, Comayagua, Honduras;University of California, San Diego, San Diego, California;Veterans Administration Medical Center, Portland, Oregon;Stanford University, Stanford, California

关键词: Chloroquine;    chronic effects;    CYP2D6;    genetic polymorphisms;    pharmacogenetics;    psychosis;    quinoline;   

DOI  :  10.1002/ccr3.238

来源: Wiley

【 摘 要 】

Key Clinical Message

Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.