Childhood‐onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2–p12.1 and two large chromosomal abnormalities at 16q22.3–q24.3 and Xq23–q28

Clinical Case Reports

Danielle Rudd²  Michael Axelsen¹  Eric A. Epping¹  Nancy Andreasen¹ 

[1] Department of Psychiatry, University of Iowa, Iowa City, Iowa;Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, Iowa

关键词: Childhood‐onset schizophrenia;    copy number variant;    cytogenetic;    partial monsomy X;    partial trisomy 16;   

DOI  :  10.1002/ccr3.192

来源: Wiley

【 摘 要 】

Key Clinical Message

Childhood-onset schizophrenia is rare, comprising 1% of known schizophrenia cases. Here, we report a patient with childhood-onset schizophrenia who has three large chromosomal abnormalities: an inherited 2.2 Mb deletion of chromosome 3p12.2–p12.1, a de novo 16.7 Mb duplication of 16q22.3–24.3, and a de novo 43 Mb deletion of Xq23–q28.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

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