Non‐autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis

Cancer Science

Masato Enomoto¹  John Vaughen¹ 

[1] Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

关键词: Cell competition;    cell death;    cellular cooperation;    cellular senescence;    tumor progression;   

DOI  :  10.1111/cas.12816

来源: Wiley

【 摘 要 】

Abstract

Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non-autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non-autonomous overgrowth. Such “oncogenic niche cells” (ONCs) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONCs depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONCs identified in Drosophila and describes the genetic basis of non-autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.