MicroRNA‐135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer

Cancer Science

Huading Zhou¹  Weijie Guo³  Yingjun Zhao²  Yifei Wang¹  Ruopeng Zha²  Jie Ding²  Linhui Liang²  Guanghua Yang¹  Zongyou Chen¹  Baojin Ma¹ 

[1] Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China;State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Medical College, Fudan University, Shanghai, China

关键词: Gallbladder cancer;    MiR‐135a;    p38;    proliferation;    very low density lipoprotein receptor;   

DOI  :  10.1111/cas.12463

来源: Wiley

【 摘 要 】

Abstract

The precise functions and mechanisms of microRNAs (miR) in gallbladder cancer (GBC) remain elusive. In this study, we found that miR-135a-5p expression is often dampened and correlated with neoplasm histologic grade in GBC. MicroRNA-135a-5p introduction clearly inhibited GBC cell proliferation in vitro and in vivo. Moreover, very low density lipoprotein receptor (VLDLR), which is often upregulated in GBC tissues, was identified as a direct functional target of miR-135a-5p. Furthermore, the p38 MAPK pathway was proven to be involved in miR-135a-VLDLR downstream signaling. Together, these results suggested that the miR-135a–VLDLR–p38 axis may contribute to GBC cell proliferation.

【 授权许可】

CC BY-NC-ND   
© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.