Association between BACH2 expression and clinical prognosis in diffuse large B‐cell lymphoma

Cancer Science

Satoshi Ichikawa⁷  Noriko Fukuhara⁷  Hiroki Katsushima⁹  Taro Takahashi¹⁰  Joji Yamamoto¹  Hisayuki Yokoyama⁵  Osamu Sasaki²  Osamu Fukuhara³  Jun Nomura⁶  Kenichi Ishizawa⁷  Ryo Ichinohasama⁴  Akihiko Muto^7,8  Kazuhiko Igarashi^7,8 

[1]Department of Internal Medicine, Sendai City Hospital, Sendai, Japan

[2]Department of Hematology, Miyagi Prefectural Cancer Center, Natori, Japan

[3]Department of Internal Medicine, Sendai Red Cross Hospital, Sendai, Japan

[4]Department of Internal Medicine, NTT East Tohoku Hospital, Sendai, Japan

[5]Department of Hematology, Sendai Medical Center, Sendai, Japan

[6]Department of Hematopathology, Tohoku University Graduate School of Medicine, Sendai, Japan

[7]Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

[8]Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

[9]Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

[10]Department of Hematology, Osaki Citizen Hospital, Osaki, Japan

关键词: BACH2;    diffuse large B‐cell lymphoma;    malignant lymphoma;    MYC;    prognostic factors;   

DOI  :  10.1111/cas.12361

来源: Wiley

【 摘 要 】

Abstract

BACH2, a B cell-specific transcriptional repressor, plays a significant role in B cell maturation. Despite a number of previous studies, the clinicopathological significance of BACH2 expression in diffuse large B cell lymphoma (DLBCL) remains to be established. The present study was performed to validate the significance of BACH2 expression as a predictor of prognosis in DLBCL. A total of 94 DLBCL cases were included in the present study. All were diagnosed between 2008 and 2011, and thorough clinical and pathological investigations were possible, including immunohistochemical analysis of BACH2. Eighteen cases were selected by positive MYC gene alteration (MYC+ group) according to cytogenetic study. The remaining 76 cases were subclassified into germinal center B cell phenotype (GCB group, 38 cases) or non-GCB phenotype (non-GCB group, 38 cases). There were no significant differences between the two groups with regard to clinical characteristics and outcomes. In the GCB group, 21 cases were judged to have high BACH2 expression, with 19 cases in the non-GCB group. In cases with high BACH2 expression in GCB and non-GCB groups, the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256). In the MYC+ group, 15 cases had high BACH2 expression levels. Although overall the MYC+ group showed short survival time (3-year OS 35.0%), 3 out of 4 cases with low BACH2 expression are alive without disease relapse at the time of publication of this paper. In conclusion, BACH2 expression level is a promising predictor of prognosis for DLBCL.

【 授权许可】

CC BY-NC-ND   
© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

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