Breast cancer molecular subtypes and survival in a hospital‐based sample in Puerto Rico

Cancer Medicine

Ana Patricia Ortiz⁴  Orquidea Frías⁶  Javier Pérez⁷  Fernando Cabanillas¹  Lisa Martínez³  Carola Sánchez⁴  David E. Capó-Ramos²  Carmen González-Keelan⁵  Edna Mora⁶ 

[1] Cancer Center, Hospital Auxilio Mutuo, San Juan, Puerto Rico;National Center for Health Statistics, Centers for Disease Control & Prevention, Maryland;School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico;Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico;Department of Pathology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico;Cancer Control and Population Sciences Program University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico;Puerto Rico Central Cancer Registry, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico

关键词: Breast cancer;    Hispanic;    Puerto Rico;    subtypes;    survival;   

DOI  :  10.1002/cam4.78

来源: Wiley

【 摘 要 】

Abstract

Information on the impact of hormone receptor status subtypes in breast cancer (BC) prognosis is still limited for Hispanics. We aimed to evaluate the association of BC molecular subtypes and other clinical factors with survival in a hospital-based female population of BC cases in Puerto Rico. We analyzed 663 cases of invasive BC diagnosed between 2002 and 2005. Information on HER-2/neu (HER-2) overexpression, estrogen (ER), and progesterone (PR) receptor status and clinical characteristics were retrieved from hospitals cancer registries and record review. Survival probabilities by covariates of interest were described using the Kaplan–Meier estimators. Cox proportional hazards models were employed to assess factors associated with risk of BC death. Overall, 17.3% of BC cases were triple-negative (TN), 61.8% were Luminal-A, 13.3% were Luminal-B, and 7.5% were HER-2 overexpressed. In the multivariate Cox model, among patients with localized stage, women with TN BC had higher risk of death (adjusted hazard ratio [HR]: 2.57, 95% confidence interval [CI]: 1.29–5.12) as compared to those with Luminal-A status, after adjusting for age at diagnosis. In addition, among women with regional/distant stage at diagnosis, those with TN BC (HR: 5.48, 95% CI: 2.63–11.47) and those HER-2+, including HER-2 overexpressed and Luminal-B, (HR: 2.73, 95% CI:1.30–5.75) had a higher mortality. This is the most comprehensive epidemiological study to date on the impact of hormone receptor expression subtypes in BC survival in Puerto Rico. Consistent to results in other populations, the TN subtype and HER-2+ tumors were associated with decreased survival.

【 授权许可】

CC BY   
© 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.