Associations among ancestry, geography and breast cancer incidence, mortality, and survival in Trinidad and Tobago

Cancer Medicine

Wayne A. Warner⁶  Robert L. Morrison⁶  Tammy Y. Lee¹  Tanisha M. Williams³  Shelina Ramnarine²  Veronica Roach⁴  Simeon Slovacek¹  Ravi Maharaj⁷  Nigel Bascombe⁷  Melissa L. Bondy⁸  Matthew J. Ellis⁸  Adetunji T. Toriola⁵  Allana Roach⁹ 

[1] California State University, Los Angeles, California;Department of Genetics, Washington University School of Medicine, St. Louis, Missouri;University of Connecticut, Storrs, California;Dr. Elizabeth Quamina Cancer Registry, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago;Department of Surgery, Washington University School of Medicine, St. Louis, Missouri;Oncology Division, Washington University School of Medicine, St. Louis, Missouri;Department of Clinical Surgical Sciences, Faculty of Medical Sciences, University of the West Indies, Trinidad and Tobago;Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas;Public Health and Primary Care Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, University of the West Indies, Trinidad and Tobago

关键词: Ancestry;    breast cancer;    Caribbean;    geography;    incidence;    mortality;    survival;    Trinidad and Tobago;   

DOI  :  10.1002/cam4.503

来源: Wiley

【 摘 要 】

Abstract

Breast cancer (BC) is the most common newly diagnosed cancer among women in Trinidad and Tobago (TT) and BC mortality rates are among the highest in the world. Globally, racial/ethnic trends in BC incidence, mortality and survival have been reported. However, such investigations have not been conducted in TT, which has been noted for its rich diversity. In this study, we investigated associations among ancestry, geography and BC incidence, mortality and survival in TT. Data on 3767 incident BC cases, reported to the National Cancer Registry of TT, from 1995 to 2007, were analyzed in this study. Women of African ancestry had significantly higher BC incidence and mortality rates (Incidence: 66.96; Mortality: 30.82 per 100,000) compared to women of East Indian (Incidence: 41.04, Mortality: 14.19 per 100,000) or mixed ancestry (Incidence: 36.72, Mortality: 13.80 per 100,000). Geographically, women residing in the North West Regional Health Authority (RHA) catchment area followed by the North Central RHA exhibited the highest incidence and mortality rates. Notable ancestral differences in survival were also observed. Women of East Indian and mixed ancestry experienced significantly longer survival than those of African ancestry. Differences in survival by geography were not observed. In TT, ancestry and geographical residence seem to be strong predictors of BC incidence and mortality rates. Additionally, disparities in survival by ancestry were found. These data should be considered in the design and implementation of strategies to reduce BC incidence and mortality rates in TT.

【 授权许可】

CC BY   
© 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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