Statin use and its effect on all‐cause mortality of melanoma patients: a population‐based Dutch cohort study

Cancer Medicine

Elisabeth Livingstone¹  Loes M. Hollestein³  Myrthe P. P. van Herk-Sukel⁴  Lonneke van de Poll-Franse²  Arjen Joosse³  Bastian Schilling¹  Tamar Nijsten³  Dirk Schadendorf¹ 

[1] Department of Dermatology, University Hospital Duisburg-Essen, Essen, Germany;CoRPS - Center of Research on Psychology in Somatic Diseases, Tilburg University, The Netherlands;Department of Dermatology, Erasmus MC University, Rotterdam, The Netherlands;PHARMO Institute for Drug Outcome Research, Utrecht, The Netherlands

关键词: HMG‐CoA reductase inhibitor;    melanoma;    statin;    survival;   

DOI  :  10.1002/cam4.285

来源: Wiley

【 摘 要 】

Abstract

Preclinical data showed anticancer effects of statins in melanoma, but meta-analyses could not demonstrate a reduced melanoma incidence in statin users. Rather than preventing occurrence, statins might reduce growth and metastatic spread of melanomas and ultimately improve survival. In this population-based study, we investigated the relationship between statin use and survival of melanoma patients. Patients ≥18 years who were diagnosed with cutaneous melanoma (Breslow thickness >1 mm) and registered in the Eindhoven Cancer Registry and in PHARMO Database Network between 1 January 1998 and 31 December 2010 were eligible. The hazard ratio (HR) of all-cause mortality was calculated by employing adjusted time-dependent and time-fixed Cox proportional hazard models. Disease-specific survival was estimated by means of 3-year relative survival rates (RSR). A control cohort of randomly selected patients using statins from PHARMO Database Network matched on age and gender was used to compare RSR of statin users to the general population. After melanoma diagnosis, 171 of 709 patients used statins. Use of statins showed a nonsignificantly decreased hazard of death (adjusted HR 0.76, 95% confidence interval [CI] 0.50–1.61). After stratification for gender, male but not female statin users showed a favorable outcome compared to nonusers (HR 0.57, 95% CI 0.32–0.99; HR 1.22, 95% CI 0.62–2.38, respectively). Three-year RSR for male statin users tended to be higher than for nonusers (91% vs. 80.5%, P = 0.06), no differences were observed in women (87.1% vs. 92.5%, P = 0.76). Statin use was not associated with an improved survival of melanoma patients. The trend for better survival of male in contrast to female statin users warrants further research.

【 授权许可】

CC BY   
© 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.