A promising randomized trial of a new therapy for obsessive–compulsive disorder

Brain and Behavior

Xian-Zhang Hu¹  You-Sheng Wen¹  Jian-Dong Ma²  Dong-Ming Han³  Yu-Xia Li³ 

[1] The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang City, Henan Province, China;Wuhan Mental Health Center (Wuhan Hospital for Psychotherapy), Tongji Medical College of Huazhong University of Science and Technique, Wuhan City, Hubei Province, China;The First Affiliated Hospital of Xinxiang medical University, Xinxiang City, Henan Province, China

关键词: Cognitive–behavioral therapy;    cognitive–coping therapy;    OCD;    remission;    response;   

DOI  :  10.1002/brb3.67

来源: Wiley

【 摘 要 】

Abstract

Pharmacotherapy and cognitive–behavioral therapy (CBT) are currently the most effective interventions for treating obsessive–compulsive disorder (OCD). These treatments, however, are time consuming and in some cases the patients do not show significant improvement. In all, 30%–60% of OCD patients do not respond adequately to pharmacotherapy and 20%–40% of OCD patients who complete CBT do not improve significantly, suggesting a more efficacious approach is needed. The objectives of this study are to demonstrate an efficacious pharmacotherapy plus psychotherapy, named cognitive–coping therapy (CCT), for OCD and to investigate the efficacy of this approach in a larger sample size. Therefore, a total of 108 patients with OCD were randomly allocated into three groups: pharmacotherapy (N = 38), pharmacotherapy plus CBT (PCBT, N = 34), and pharmacotherapy plus CCT (PCCT, N = 36). The severity of symptoms and the patients' functioning were assessed pretreatment and after 7, 14, 21 days, and 1-, 3-, 6-, and 12-month treatment using the Yale-Brown Obsessive Compulsive Scale and Global Assessment of Functioning (GAF). Compared with the pharmacotherapy and PCBT groups, the severity of OCD symptoms was significantly reduced (P < 0.001), the rates of response (100%) and remission (85.0%) were significantly higher (P < 0.001), and relapse rate was lower (P = 0.017) in PCCT group during the 1-year follow-up. In addition, the GAF score was significantly higher in the PCCT group than in the other two groups (P < 0.001). Our preliminary data suggest that PCCT is a more efficacious psychotherapy for OCD patients than pharmacotherapy or PCBT.

【 授权许可】

CC BY-NC   
© 2012 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

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