The ANKK1/DRD2 locus is a genomic substrate for affective priming and recognition of angry faces

Brain and Behavior

Alejandra Koeneke²  Guillermo Ponce¹  Janet Hoenicka³ 

[1] Instituto de Investigación Sanitaria Hospital 12 de Octubre, Madrid, Spain;Faculty of Psychology, Complutense University of Madrid, Madrid, Spain;Program in Rare and Genetic Diseases & IBV/CSIC Associated Unit, Centro de Investigación Príncipe Felipe, Valencia, Spain

关键词: Affective priming;    ANKK1;    DRD2;    endophenotype;    facial expression recognition;    psychopathy;   

DOI  :  10.1002/brb3.405

来源: Wiley

【 摘 要 】

Abstract

Introduction

Ankyrin repeat and kinase domain containing I (ANKK1) and dopamine D2 receptor (DRD2) genes have been associated with psychopathic traits in clinical samples. On the other hand, individuals high in psychopathy show reduced affective priming and deficits in facial expression recognition. We have hypothesized that these emotion-related cognitive phenomena are associated with TaqIA (rs18000497) SNP (single nucleotide polymorphism) of the ANKK1 gene and with C957T (rs6277) SNP of the DRD2 gene.

Methods

We performed a genetic association analysis in 94 self-reported Caucasian healthy volunteers. The participants completed 144 trials of an affective priming task, in which primes and targets were emotional words. They also had to recognize 64 facial expressions of happiness, sadness, anger, and fear in an expression recognition task. Regarding the genetic analyses, TaqIA and C957T SNPs were genotyped.

Results

We found that the C957T SNP TT genotype was associated with a stronger priming effect and a better recognition of angry expressions. No associations were found for the TaqIA SNP. In addition, in silico analysis demonstrated that C957T SNP is a marker of a regulatory sequence at the 5′ UTR of ANKK1 gene, thus suggesting the involvement of the whole ANKK1/DRD2 locus in cognitive–emotional processing.

Conclusions

These results suggest that affective priming and recognition of angry facial expressions are endophenotypes that lie on the pathway between the ANKK1/DRD2 locus and some deviant phenotypes.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

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