Dynamic disconnection of the supplementary motor area after processing of dismissive biographic narratives

Brain and Behavior

Viola Borchardt⁴  Anna L. Krause⁶  Meng Li⁶  Marie-José van Tol²  Liliana Ramona Demenescu⁶  Anna Buchheim¹  Coraline D. Metzger⁴  Catherine M. Sweeney-Reed⁵  Tobias Nolte³  Anton R. Lord⁴ 

[1] Institute of Psychology, University of Innsbruck, Innsbruck, Austria;University of Groningen, University Medical Center Groningen, Neuroimaging Center, Groningen, the Netherlands;Anna Freud Centre, London, UK;Leibniz Institute for Neurobiology, Magdeburg, Germany;Department of Neurology, Otto von Guericke University, Magdeburg, Germany;Clinical Affective Neuroimaging Laboratory, Magdeburg, Germany

关键词: Acoustic stimulation;    adult attachment representation;    cognitive affective neuroscience;    fMRI;    functional connectivity;    graph theory;    human social interactions;    resting‐state;   

DOI  :  10.1002/brb3.377

来源: Wiley

【 摘 要 】

Abstract

Introduction

To understand the interplay between affective social information processing and its influence on mental states we investigated changes in functional connectivity (FC) patterns after audio exposure to emotional biographic narratives.

Methods

While lying in the 7T MR scanner, 23 male participants listened to narratives of early childhood experiences of three persons, each having either a secure, dismissing, or preoccupied attachment representation. Directly after having listened to each of the prototypical narratives, participants underwent a 10-minute resting-state fMRI scan.

To study changes in FC patterns between experimental conditions, three post-task conditions were compared to a baseline condition. Specific local alterations, as well as differences in connectivity patterns between distributed brain regions, were quantified using Network-based statistics (NBS) and graph metrics.

Results

Using NBS, a nine-region subnetwork showing reduced FC after having listened to the dismissing narrative was identified. Of this subnetwork, only the left Supplementary Motor Area (SMA) exhibited a decrease in the nodal graph metrics degree and strength exclusively after listening to the dismissing narrative. No other region showed post-task changes in nodal metrics. A post hoc analysis of dynamic characteristics of FC of the left SMA showed a significant decrease in the dismissing condition when compared with the other conditions in the first three minutes of the scan, but faded away in the two subsequent intervals the differences.

Conclusions

Nodal metrics and NBS converge on reduced connectivity measures exclusively in left SMA in the dismissing condition, which may specifically reflect ongoing network changes underlying prolonged emotional reactivity to attachment-related processing.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.