Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease

Brain and Behavior

Shunichiro Shinagawa¹  Adhimoolam Babu¹  Virginia Sturm¹  Tal Shany-Ur¹  Parnian Toofanian Ross¹  Diana Zackey¹  Pardis Poorzand¹  Scott Grossman¹  Bruce L. Miller¹ 

[1] Memory and Aging Center, Department of Neurology, University of California, San Francisco, California

关键词: Alzheimer's disease;    behavior inhibition;    dementia;    frontotemporal dementia;    neurodegeneration;    social concern;    voxel‐based morphometry;   

DOI  :  10.1002/brb3.350

来源: Wiley

【 摘 要 】

Abstract

Introduction

The Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been theorized as neural systems that regulate approach/withdrawal behaviors. Behavioral activation/inhibition balance may change in neurodegenerative disease based on underlying alterations in systems supporting motivation and approach/withdrawal behaviors, which may in turn be reflected in neuropsychiatric symptoms.

Method

A total of 187 participants (31 patients diagnosed with behavioral variant of FTD [bvFTD], 13 semantic variant of primary progressive aphasia [svPPA], 14 right temporal variant FTD [rtFTD], 54 Alzheimer's disease [AD], and 75 older healthy controls [NCs]) were included in this study. Changes in behavioral inhibition/activation were measured using the BIS/BAS scale. We analyzed the correlation between regional atrophy pattern and BIS/BAS score, using voxel-based morphometry (VBM).

Results

ADs had significantly higher BIS scores than bvFTDs and NCs. bvFTDs activation-reward response (BAS-RR) was significantly lower than ADs and NCs, though their activation-drive (BAS-D) was significantly higher than in ADs. Both AD and rtFTD patients had abnormally low activation fun-seeking (BAS-FS) scores. BIS score correlated positively with right anterior cingulate and middle frontal gyrus volume, as well as volume in the right precentral gyrus and left insula/operculum.

Conclusions

AD, bvFTD, and rtFTD patients show divergent patterns of change in approach/withdrawal reactivity. High BIS scores correlated with preservation of right-predominant structures involved in task control and self-protective avoidance of potentially negative reinforcers. Damage to these regions in bvFTD may create a punishment insensitivity that underlies patients’ lack of self-consciousness in social contexts.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

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