A P300‐based cognitive assessment battery

Brain and Behavior

Aaron Kirschner²  Damian Cruse²  Srivas Chennu¹  Adrian M. Owen² 

[1] Department of Clinical Neurosciences, The University of Cambridge, Cambridge, UK;The Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada

关键词: Attention;    cognitive assessment;    EEG;    P300;    reasoning;    working memory;   

DOI  :  10.1002/brb3.336

来源: Wiley

【 摘 要 】

Abstract

Background

It is well established that some patients who are diagnosed as being in a vegetative state or a minimally conscious state show reliable signs of volition that may only be detected by measuring neural responses. A pertinent question is whether these patients are capable of higher cognitive processes.

Methods

Here, we develop a series of EEG paradigms that probe several core aspects of cognition at the bedside without the need for motor responses and explore the sensitivity of this approach in a group of healthy controls.

Results

Using analysis of ERPs alone, this method can determine with high reliability whether individual participants are able to attend a stimulus stream, maintain items in working memory, or solve complex grammatical reasoning problems.

Conclusion

We suggest that this approach could form the basis of a brain-based battery for assessing higher cognition in patients with severe motor impairments or disorders of consciousness.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.