Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson's disease

Brain and Behavior

Lewis Kass-Iliyya²  Christopher Kobylecki²  Kathryn R. McDonald¹  Alexander Gerhard² 

[1] Centre for Clinical and Cognitive Neurosciences, Institute of Brain Behaviour and Mental Health, University of Manchester, Manchester, U.K;Department of Neurology, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford, U.K

关键词: Multiple system atrophy;    neuropathic;    pain;    Parkinson's disease;    progressive supranuclear palsy;   

DOI  :  10.1002/brb3.320

来源: Wiley

【 摘 要 】

Abstract

Background

Pain is a common nonmotor symptom in Parkinson's disease (PD). The pathophysiology of pain in PD is not well understood. Pain characteristics have rarely been studied in atypical parkinsonian disorders such as Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP).

Aim of the study

We aimed to evaluate pain intensity, location, and associated symptoms in atypical parkinsonian disorders compared to PD.

Methods

Twenty-one patients with MSA, 16 patients with PSP, and 65 patients with PD were screened for pain using question 1.9 of the MDS-UPDRS. Pain intensity was quantified using the short form McGill Pain Questionnaire (SFMPQ). Pain locations were documented. Motor disability was measured using UPDRS-III. Affective symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS).

Results

Pain was significantly more common and more severe in PD and MSA compared to PSP (P < 0.01). Pain locations were similar with limb pain being the most common followed by neck and back pain. Pain intensity correlated with HADS scores but not motor severity.

Conclusions

Pain is more common and more intense in PD and MSA than PSP. Differences in distribution of neurodegenerative pathologies may underlie these differential pain profiles.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

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