Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report

Brain and Behavior

Ryuji Uehara¹  Koji Yamashita¹  Akio Hiwatashi¹  Osamu Togao¹  Kazufumi Kikuchi¹  Jun Yokoyama²  Dai Matsuse²  Takashi Yoshiura¹ 

[1] Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

关键词: Diffusion MRI;    IVIM;    MELAS;    perfusion MRI;   

DOI  :  10.1002/brb3.282

来源: Wiley

【 摘 要 】

Abstract

Objective

We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase.

Results

On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas.

Conclusion

These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.

【 授权许可】

CC BY   
© 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.