First use of 18F‐labeled ML‐10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy

Brain and Behavior

Matthew J. Oborski²  Charles M. Laymon²  Frank S. Lieberman³  Jan Drappatz³  Ronald L. Hamilton¹ 

[1] Department of Pathology, Division of Neuropathology, University of Pittsburgh, Pittsburgh, Pennsylvania;Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania;Department of Neurology and Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

关键词: 18F‐ML‐10;    early‐therapy response assessment;    glioblastoma multiforme;    positron emission tomography;   

DOI  :  10.1002/brb3.217

来源: Wiley

【 摘 要 】

Abstract

Objectives

The authors present the first use of the novel positron emission tomography (PET) apoptosis tracer ¹⁸F-labeled 2-(5-fluoro-pentyl)-2-methyl-malonic acid (¹⁸F-ML-10) for early-therapy response assessment of a newly diagnosed glioblastoma multiforme (GBM) patient.

Case report

A 71-year-old male with a newly diagnosed GBM received ¹⁸F-ML-10 PET scans prior to therapy initiation (baseline) and after completing 3 weeks of whole-brain radiation therapy with concomitant temozolomide chemotherapy (early-therapy assessment, ETA). The baseline ¹⁸F-ML-10 PET scan showed increased tracer uptake at the site of the GBM, with highest activity toward the central portion of the tumor. At the ETA time point, a new distribution of tracer uptake was observed compared to baseline. Normalized pixel-by-pixel subtraction of baseline from ETA was used to quantify change in tracer distribution between ¹⁸F-ML-10 PET imaging time points. Results of this analysis showed reduction in ¹⁸F-ML-10 uptake at the site of greatest baseline uptake, but increased uptake around the periphery of the tumor at the early-therapy time point.

Conclusion

The changing patterns of ¹⁸F-ML-10 uptake between baseline and ETA are suggestive for therapy-induced tumor cellular apoptosis.

【 授权许可】

CC BY   
© 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

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