Abnormal cortical sensorimotor activity during “Target” sound detection in subjects with acute acoustic trauma sequelae: an fMRI study

Brain and Behavior

Agnès Job⁵  Yoann Pons⁴  Laurent Lamalle²  Assia Jaillard²  Karl Buck¹  Christoph Segebarth³ 

[1] Institut franco-allemand de recherche de Saint-Louis, Saint Louis, France;INSERM IFR1, Plate-forme régionale 3T, Grenoble, France;INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France;Hôpital d’instruction des Armées du Val-de-Grâce, 75 bld de Port-Royal, Paris, France;Institut de Recherche Biomédicale des Armées, antenne CRSSA, La Tronche, France

关键词: Acoustic trauma;    fMRI;    Middle ear;    Proprioception;    Tinnitus;   

DOI  :  10.1002/brb3.21

来源: Wiley

【 摘 要 】

Abstract

The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory “oddball” attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

【 授权许可】

CC BY-NC   
© 2012 The Authors. MicrobiologyOpen published by Blackwell Publishing Ltd.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.