Pilot data on telmisartan short‐term effects on glucose metabolism in the olfactory tract in Alzheimer's disease

Brain and Behavior

Etsuko Imabayashi²  Hiroshi Matsuda²  Kimiko Yoshimaru³  Ichiei Kuji²  Akira Seto¹  Yasumasa Shimano²  Kimiteru Ito²  Daisuke Kikuta²  Tomokazu Shimazu³ 

[1] Department of Nuclear Medicine, Saitama Medial University Hospital, 38 Morohongo, Moroyama, Iruma-gun, Saitama, Japan;Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, Japan;Department of Neurology, Saitama Medial University Hospital, 38 Morohongo, Moroyama, Iruma-gun, Saitama, Japan

关键词: Alzheimer's disease (AD);    angiotensin II receptor blocker (ARB);    telmisartan;    18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET);    anterior olfactory nucleus;   

DOI  :  10.1002/brb3.13

来源: Wiley

【 摘 要 】

Abstract

The possible effect of antihypertensive therapy on Alzheimer's disease (AD) has been studied, and angiotensin II receptor blockers (ARBs) have been suggested to exert an effect on cognitive decline. The purpose of this study is to clarify the functional effects of telmisartan, a long-acting ARB, on AD brain using prospective longitudinal ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) studies. For this purpose, brain glucose metabolism of four hypertensive patients with AD was examined with FDG-PET before and after administration of telmisartan. Studied subjects underwent three FDG-PET studies at intervals of 12 weeks. Antihypertensive treatment except for telmisartan was started after the first FDG-PET and continued for 24 weeks. Then 40–80 mg of telmisartan was added after the second FDG-PET and continued for 12 weeks.Glucose metabolism was significantly decreased during the first 12 weeks without telmisartan use at an area (−10, 21, −22, x, y, z; Z = 3.56) caudal to the left rectal gyrus and the olfactory sulcus corresponding to the left olfactory tract. In contrast, the introduction of telmisartan during the following 12 weeks preserved glucose metabolism at areas (5, 19, −20, x, y, z; Z = 3.09; 6, 19, −22, x, y, z; Z = 2.88) caudal to the bilateral rectal gyri and olfactory sulci corresponding to the bilateral olfactory tracts. No areas showed decreased glucose metabolism after the introduction of telmisartan. In AD, amyloid-β deposition is observed in the anterior olfactory nucleus (AON) of the olfactory tract. Glucose metabolism in AON may be progressively decreased and preserved by telmisartan.

【 授权许可】

CC BY-NC   
©2011 The Authors. Brain and Behavior published by Blackwell Publishing Ltd.

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