Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

Advanced Science

Anwarul Hasan¹  Ahmad Khattab⁴  Mohammad Ariful Islam³  Khaled Abou Hweij⁷  Joya Zeitouny⁴  Renae Waters²  Malek Sayegh⁶  Md Monowar Hossain⁵ 

[1] Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA;BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA;Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA;Department of Electrical and Computer Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon;Department of Medicine, Lyell McEwin Hospital, University of Adelaide, Australia;Hamilton College, Clinton, NY, USA;Department of Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon

关键词: hydrogels;    myocardial infarction;    tissue engineering;    regenerative medicine;    cardiac repair;    stem cell;   

DOI  :  10.1002/advs.201500122

来源: Wiley

【 摘 要 】

Abstract

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI.

【 授权许可】

CC BY   
© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.