Virus‐Surface‐Mimicking Surface Clustering of AuNPs onto DNA‐Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster‐Induced NIR Photothermal Therapy

Advanced Science

Hui-Zhen Jia³  Wei-Hai Chen³  Xuli Wang²  Qi Lei³  Wei-Na Yin³  Yan Wang¹  Ren-Xi Zhuo³  Jun Feng³ 

[1] Institute of Hydrobiology, Chinese Academy of Sciences Analysis and Testing Center, Wuhan, P.R. China;Department of Phamaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA;Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, P.R. China

关键词: cellular entry;    gene transfection;    gold nanoparticles;    photothermal therapy;    virus‐surface mimicking;   

DOI  :  10.1002/advs.201500108

来源: Wiley

【 摘 要 】

Abstract

Virus-surface-mimicking decoration of deoxyribonucleic acid (DNA)-entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near-infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic–inorganic nanoplatform, especially for cancer treatments.

【 授权许可】

CC BY   
© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.