The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?

Aging Cell

Noriyuki Fuku⁴  Helios Pareja-Galeano²  Hirofumi Zempo⁴  Rafael Alis¹  Yasumichi Arai³  Alejandro Lucia² 

[1] Research Institute ‘Dr. Viña Giner’, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain;European University of Madrid, Madrid, Spain;Center for Supercentenarian Study, Keio University School of Medicine, Tokyo, Japan;Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan

关键词: aging;    centenarians;    longevity gene;    longevity regulation;    mitochondria;    mitochondrial DNA;    mitochondrial DNA abnormalities;    molecular biology of aging;   

DOI  :  10.1111/acel.12389

来源: Wiley

【 摘 要 】

Summary

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

【 授权许可】

CC BY   
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.