The life‐extending effect of dietary restriction requires Foxo3 in mice

Aging Cell

Isao Shimokawa¹  Toshimitsu Komatsu¹  Nobutaka Hayashi¹  Sang-Eun Kim¹  Takuya Kawata¹  Seongjoon Park¹  Hiroko Hayashi¹  Haruyoshi Yamaza¹  Takuya Chiba¹ 

[1] Department of Pathology, Nagasaki University School of Medicine and Graduate School of Biomedical Sciences, Nagasaki, Japan

关键词: cancer;    dietary restriction;    Foxo;    lifespan;    longevity;    mouse;   

DOI  :  10.1111/acel.12340

来源: Wiley

【 摘 要 】

Summary

Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (^+/–) and homozygous (^–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3^+/– or Foxo3^–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3^+/–, and Foxo3^–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3^+/– mice contrast with those in Foxo1^+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

【 授权许可】

CC BY   
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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